Can we regenerate a large bony defect, especially when a previously autogenous bone graft therapy has failed? In this talk, Dr. Markus Tröltzsch addresses this challenge, by using a customized titanium mesh and a combination of Geistlich Bio-Oss and autogenous bone to reconstruct the large vertical and lateral defect of the mandible in compromised patients. He highlights the importance of pre-planning, following the surgical protocol, and patient communication.